DNA modifications by antitumor trans-[PtCl2(E-iminoether)2]
Language English Country Netherlands Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
9281596
DOI
10.1124/mol.52.3.354
PII: S0026-895X(24)13334-2
Knihovny.cz E-resources
- MeSH
- Chemical Phenomena MeSH
- Cisplatin pharmacology MeSH
- DNA chemistry drug effects metabolism MeSH
- Chemistry, Physical MeSH
- Transcription, Genetic drug effects MeSH
- Nucleic Acid Conformation drug effects MeSH
- Organometallic Compounds pharmacology MeSH
- Antineoplastic Agents pharmacology MeSH
- Cattle MeSH
- Drug Stability MeSH
- Stereoisomerism MeSH
- Substrate Specificity MeSH
- DNA, Superhelical drug effects metabolism MeSH
- Animals MeSH
- Check Tag
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Cisplatin MeSH
- dichloroplatinum(E-iminoether)2 MeSH Browser
- DNA MeSH
- Organometallic Compounds MeSH
- Antineoplastic Agents MeSH
- DNA, Superhelical MeSH
- transplatin MeSH Browser
Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)2], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeutically active. Global modifications of natural DNAs in cell-free media by trans-[PtCl2(E-iminoether)2] were studied through various molecular biophysical methods and compared with modifications by cis-[PtCl2(E-iminoether)2], transplatin, cisplatin, and monofunctional chlorodiethylenetriamineplatinum(II) chloride. Thus, the results of this study have extended our recent finding, indicating that the prevalent lesion occurring in double-helical DNA on its modification by trans-[PtCl2(E-iminoether)2] is a monofunctional adduct at guanine residues. The modification by trans-[PtCl2(E-iminoether)2] has been found to induce local distortions in DNA, which have a character differing fundamentally from those induced by both clinically ineffective or antitumor platinum complexes tested in this study. The different character of alterations induced in DNA by the adducts of trans-[PtCl2(E-iminoether)2] and transplatin has been suggested to be relevant to the unexpected observation that the new complex with leaving chloride groups in trans position exhibits antitumor efficacy. In addition, the results support the idea that platinum drugs that bind to DNA in a manner fundamentally different from that of cisplatin can exhibit altered biological properties, including differing spectra and intensities of antitumor activity.
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