DNA modifications by antitumor trans-[PtCl2(E-iminoether)2]
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
9281596
DOI
10.1124/mol.52.3.354
PII: S0026-895X(24)13334-2
Knihovny.cz E-zdroje
- MeSH
- antitumorózní látky farmakologie MeSH
- chemické jevy MeSH
- chemie fyzikální MeSH
- cisplatina farmakologie MeSH
- DNA chemie účinky léků metabolismus MeSH
- genetická transkripce účinky léků MeSH
- konformace nukleové kyseliny účinky léků MeSH
- organokovové sloučeniny farmakologie MeSH
- skot MeSH
- stabilita léku MeSH
- stereoizomerie MeSH
- substrátová specifita MeSH
- superhelikální DNA účinky léků metabolismus MeSH
- zvířata MeSH
- Check Tag
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- antitumorózní látky MeSH
- cisplatina MeSH
- dichloroplatinum(E-iminoether)2 MeSH Prohlížeč
- DNA MeSH
- organokovové sloučeniny MeSH
- superhelikální DNA MeSH
- transplatin MeSH Prohlížeč
Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)2], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeutically active. Global modifications of natural DNAs in cell-free media by trans-[PtCl2(E-iminoether)2] were studied through various molecular biophysical methods and compared with modifications by cis-[PtCl2(E-iminoether)2], transplatin, cisplatin, and monofunctional chlorodiethylenetriamineplatinum(II) chloride. Thus, the results of this study have extended our recent finding, indicating that the prevalent lesion occurring in double-helical DNA on its modification by trans-[PtCl2(E-iminoether)2] is a monofunctional adduct at guanine residues. The modification by trans-[PtCl2(E-iminoether)2] has been found to induce local distortions in DNA, which have a character differing fundamentally from those induced by both clinically ineffective or antitumor platinum complexes tested in this study. The different character of alterations induced in DNA by the adducts of trans-[PtCl2(E-iminoether)2] and transplatin has been suggested to be relevant to the unexpected observation that the new complex with leaving chloride groups in trans position exhibits antitumor efficacy. In addition, the results support the idea that platinum drugs that bind to DNA in a manner fundamentally different from that of cisplatin can exhibit altered biological properties, including differing spectra and intensities of antitumor activity.
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