Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats
Language English Country England, Great Britain Media print
Document type Comparative Study, Journal Article
- MeSH
- Acetylcholinesterase metabolism MeSH
- Antidotes therapeutic use MeSH
- Benactyzine administration & dosage therapeutic use MeSH
- Diaphragm enzymology MeSH
- Chemical Warfare Agents toxicity MeSH
- Cholinesterase Inhibitors toxicity MeSH
- Respiration drug effects MeSH
- Electrocardiography MeSH
- Drug Therapy, Combination MeSH
- Blood Pressure drug effects MeSH
- Rats MeSH
- Brain enzymology MeSH
- Central Nervous System Diseases chemically induced drug therapy MeSH
- Oximes MeSH
- Rats, Wistar MeSH
- Pyridinium Compounds therapeutic use MeSH
- Pyridostigmine Bromide administration & dosage MeSH
- Cholinesterase Reactivators therapeutic use MeSH
- Soman toxicity MeSH
- Heart Rate drug effects MeSH
- Trihexyphenidyl administration & dosage MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Antidotes MeSH
- asoxime chloride MeSH Browser
- Benactyzine MeSH
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Pyridostigmine Bromide MeSH
- Cholinesterase Reactivators MeSH
- Soman MeSH
- Trihexyphenidyl MeSH
1 The effect of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated Panpal, and antidotal treatment (the oxime HI-6 plus benactyzine) in soman poisoning was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2 Soman poisoning caused a high decrease in respiratory rate as well as minute respiratory volume and an increase in mean arterial pressure from 30-120 min following soman challenge. Soman at sublethal dose also significantly inhibited acetylcholinesterase activity in diaphragm and various brain parts. 3 Panpal pretreatment as well as antidotal treatment were effective in improving the respiratory and circulatory function disturbed by soman without the ability to increase significantly soman-inhibited acetylcholinesterase activity in all brain parts studied. 4 The efficacy of combined Panpal pretreatment and antidotal treatment against sublethal soman poisoning was not different from the efficacy of Panpal pretreatment or antidotal treatment alone. 5 The results of this investigation suggest that Panpal pretreatment as well as antidotal treatment are able to restore respiratory and circulatory function in soman-poisoned rats without significant reactivation of brain acetylcholinesterase.
References provided by Crossref.org
Combined Pre- and Posttreatment of Paraoxon Exposure
