Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu srovnávací studie, časopisecké články
- MeSH
- acetylcholinesterasa metabolismus MeSH
- antidota terapeutické užití MeSH
- benaktyzin aplikace a dávkování terapeutické užití MeSH
- bránice enzymologie MeSH
- chemické bojové látky toxicita MeSH
- cholinesterasové inhibitory toxicita MeSH
- dýchání účinky léků MeSH
- elektrokardiografie MeSH
- kombinovaná farmakoterapie MeSH
- krevní tlak účinky léků MeSH
- krysa rodu Rattus MeSH
- mozek enzymologie MeSH
- nemoci centrálního nervového systému chemicky indukované farmakoterapie MeSH
- oximy MeSH
- potkani Wistar MeSH
- pyridinové sloučeniny terapeutické užití MeSH
- pyridostigmin-bromid aplikace a dávkování MeSH
- reaktivátory cholinesterasy terapeutické užití MeSH
- soman toxicita MeSH
- srdeční frekvence účinky léků MeSH
- trihexyfenidyl aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- antidota MeSH
- asoxime chloride MeSH Prohlížeč
- benaktyzin MeSH
- chemické bojové látky MeSH
- cholinesterasové inhibitory MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- pyridostigmin-bromid MeSH
- reaktivátory cholinesterasy MeSH
- soman MeSH
- trihexyfenidyl MeSH
1 The effect of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated Panpal, and antidotal treatment (the oxime HI-6 plus benactyzine) in soman poisoning was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2 Soman poisoning caused a high decrease in respiratory rate as well as minute respiratory volume and an increase in mean arterial pressure from 30-120 min following soman challenge. Soman at sublethal dose also significantly inhibited acetylcholinesterase activity in diaphragm and various brain parts. 3 Panpal pretreatment as well as antidotal treatment were effective in improving the respiratory and circulatory function disturbed by soman without the ability to increase significantly soman-inhibited acetylcholinesterase activity in all brain parts studied. 4 The efficacy of combined Panpal pretreatment and antidotal treatment against sublethal soman poisoning was not different from the efficacy of Panpal pretreatment or antidotal treatment alone. 5 The results of this investigation suggest that Panpal pretreatment as well as antidotal treatment are able to restore respiratory and circulatory function in soman-poisoned rats without significant reactivation of brain acetylcholinesterase.
Citace poskytuje Crossref.org
Combined Pre- and Posttreatment of Paraoxon Exposure
