Hydrophobicity and outer membrane proteins of Shigella dysenteriae type 1 after treatment with subinhibitory concentrations of aminoglycosides
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
9438357
DOI
10.1007/bf02815466
Knihovny.cz E-resources
- MeSH
- Amikacin administration & dosage pharmacology MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Cell Wall chemistry drug effects MeSH
- Chemical Phenomena MeSH
- Electrophoresis, Polyacrylamide Gel MeSH
- Chemistry, Physical MeSH
- Gentamicins administration & dosage pharmacology MeSH
- Bacterial Outer Membrane Proteins chemistry MeSH
- Shigella dysenteriae drug effects metabolism MeSH
- Tobramycin administration & dosage pharmacology MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Amikacin MeSH
- Anti-Bacterial Agents MeSH
- Gentamicins MeSH
- Bacterial Outer Membrane Proteins MeSH
- Tobramycin MeSH
Hydrophobicity and profiles of outer membrane proteins of Shigella dysenteriae type 1 after treatment with subinhibitory concentrations (1/2 or 1/4 of the MIC) of aminoglycosides were studied. The antimicrobial activity of the antibiotics tested was 3.12 mg/L (amikacin, tobramycin) and 6.25 mg/L (gentamicin). The hydrophobicity of the cell surface of S. dysenteriae type 1 was decreased after exposure to all aminoglycosides at a concentration of 1/2 of the MICs; 1/4 of the MICs of the antibiotics did not affect bacterial aggregation in the presence of ammonium sulfate. SDS-polyacrylamide gel electrophoresis showed that the profiles of outer membrane proteins of the strain treated with aminoglycosides at both subinhibitory concentrations were not changed as compared to the control.
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