The effect of chronic L-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats
Language English Country Netherlands Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
9548391
DOI
10.1016/s0014-2999(97)01505-7
PII: S0014-2999(97)01505-7
Knihovny.cz E-resources
- MeSH
- Hypertension blood genetics physiopathology MeSH
- Carnitine blood pharmacology MeSH
- Blood Pressure drug effects MeSH
- Rats MeSH
- Uric Acid blood MeSH
- Lipids blood MeSH
- Rats, Inbred SHR MeSH
- Rats, Inbred WKY MeSH
- Heart Rate drug effects MeSH
- Body Weight drug effects MeSH
- Organ Size drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Carnitine MeSH
- Uric Acid MeSH
- Lipids MeSH
The effect of chronic L-carnitine treatment on blood pressure and plasma lipids was studied in spontaneously hypertensive rats (SHR). L-Carnitine treatment for 6 weeks lowered significantly both the systolic and mean arterial pressure of SHR but its influence on diastolic and pulse pressure was only modest. L-Carnitine did not influence the relative heart and kidney weight of SHR. However, L-carnitine completely abolished the age-dependent rise of plasma total cholesterol, triglycerides and uric acid seen in untreated SHR. On the other hand, L-carnitine treatment had no significant effects on blood pressure, relative organ weight and plasma lipids in normotensive Wistar-Kyoto rats. Our results suggest that L-carnitine might prevent some cardiovascular alterations by its influence on lipid metabolism.
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