Anticonvulsant action of gabapentin during postnatal development in rats
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Acetates pharmacology MeSH
- Amines * MeSH
- Anticonvulsants pharmacology MeSH
- Behavior, Animal drug effects physiology MeSH
- Epilepsy, Generalized chemically induced prevention & control MeSH
- Epilepsy, Tonic-Clonic chemically induced prevention & control MeSH
- gamma-Aminobutyric Acid * MeSH
- Gabapentin MeSH
- Rats MeSH
- Cyclohexanecarboxylic Acids * MeSH
- Brain drug effects growth & development MeSH
- Pentylenetetrazole * MeSH
- Rats, Wistar MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetates MeSH
- Amines * MeSH
- Anticonvulsants MeSH
- gamma-Aminobutyric Acid * MeSH
- Gabapentin MeSH
- Cyclohexanecarboxylic Acids * MeSH
- Pentylenetetrazole * MeSH
PURPOSE: To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS: Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizures [minimal (i.e., clonic)] and generalized tonic-clonic (GTCS) were recorded, and seizure severity was scored. RESULTS: GBP suppressed or at least restricted the tonic phase of GTCS at all the developmental stages studied. In addition, minimal seizures were suppressed in 18-day-old rats. Both effects exhibited a tendency to a U-shaped dose-response curve. CONCLUSIONS: Anticonvulsant effects of GBP were demonstrated in immature and in adult rats.
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Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
