Anticonvulsant action of gabapentin during postnatal development in rats
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- acetáty farmakologie MeSH
- aminy * MeSH
- antikonvulziva farmakologie MeSH
- chování zvířat účinky léků fyziologie MeSH
- epilepsie generalizovaná chemicky indukované prevence a kontrola MeSH
- epilepsie tonicko-klonická chemicky indukované prevence a kontrola MeSH
- GABA * MeSH
- gabapentin MeSH
- krysa rodu Rattus MeSH
- kyseliny cyklohexankarboxylové * MeSH
- mozek účinky léků růst a vývoj MeSH
- pentylentetrazol * MeSH
- potkani Wistar MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- záchvaty chemicky indukované prevence a kontrola MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- acetáty MeSH
- aminy * MeSH
- antikonvulziva MeSH
- GABA * MeSH
- gabapentin MeSH
- kyseliny cyklohexankarboxylové * MeSH
- pentylentetrazol * MeSH
PURPOSE: To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS: Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizures [minimal (i.e., clonic)] and generalized tonic-clonic (GTCS) were recorded, and seizure severity was scored. RESULTS: GBP suppressed or at least restricted the tonic phase of GTCS at all the developmental stages studied. In addition, minimal seizures were suppressed in 18-day-old rats. Both effects exhibited a tendency to a U-shaped dose-response curve. CONCLUSIONS: Anticonvulsant effects of GBP were demonstrated in immature and in adult rats.
Citace poskytuje Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
