Effects of K+-depolarization, arachidonic acid, ethanol, and aging on the high-affinity choline transport in rat hippocampus
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
9690733
DOI
10.1023/a:1021025302664
Knihovny.cz E-zdroje
- MeSH
- biologický transport MeSH
- cholin metabolismus MeSH
- draslík farmakologie MeSH
- ethanol farmakologie MeSH
- hemicholinium 3 metabolismus MeSH
- hipokampus účinky léků metabolismus MeSH
- krysa rodu Rattus MeSH
- kyselina arachidonová farmakologie MeSH
- potkani Wistar MeSH
- stárnutí metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cholin MeSH
- draslík MeSH
- ethanol MeSH
- hemicholinium 3 MeSH
- kyselina arachidonová MeSH
The Na+-dependent high-affinity choline uptake (HACU) transport and the [3H]hemicholinium-3 ([3H]HC-3) specific binding were measured on hippocampal synaptosomes of young (3-6 months) and old (22 months) Wistar rats. In vitro effects of 100-300 microM arachidonic acid (AA) and of 5% ethanol were tested under basal as well as stimulated (55 mM KCl) conditions. The influence of AA (an irreversible decrease of HACU and a reversible increase of [3H]HC-3 binding) was more marked under stimulated rather than basal conditions in brain tissue of young rats. The increased K+-depolarization effect on HACU and the decreased influence of AA on [3H]HC-3 binding were estimated in brain tissue of old compared to young rats. Results suggest the involvement of different pools of the high-affinity choline carrier and marked changes due to aging in the regulation of the HACU transport.
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