Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens
Language English Country United States Media print
Document type Journal Article
PubMed
10224656
DOI
10.1002/(sici)1520-636x(1999)11:4<291::aid-chir6>3.0.co;2-4
PII: 10.1002/(SICI)1520-636X(1999)11:4<291::AID-CHIR6>3.0.CO;2-4
Knihovny.cz E-resources
- MeSH
- Anti-Inflammatory Agents, Non-Steroidal chemistry isolation & purification MeSH
- Butyrates chemistry isolation & purification MeSH
- Ergolines chemistry isolation & purification MeSH
- Molecular Conformation MeSH
- Models, Molecular MeSH
- Molecular Structure MeSH
- Propionates chemistry isolation & purification MeSH
- Stereoisomerism MeSH
- Chromatography, High Pressure Liquid methods MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Inflammatory Agents, Non-Steroidal MeSH
- Butyrates MeSH
- Ergolines MeSH
- flobufen MeSH Browser
- Propionates MeSH
The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
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