Function of the isolated perfused kidneys from young or adult rats with post-DOCA-salt hypertension
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- cévní rezistence MeSH
- deoxykortikosteron toxicita MeSH
- hodnoty glomerulární filtrace MeSH
- hypertenze chemicky indukované patofyziologie moč MeSH
- krevní tlak MeSH
- krysa rodu Rattus MeSH
- ledviny krevní zásobení patofyziologie MeSH
- modely nemocí na zvířatech MeSH
- perfuze MeSH
- potkani Wistar MeSH
- renální oběh fyziologie MeSH
- sodík moč MeSH
- stárnutí fyziologie MeSH
- velikost orgánu MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- deoxykortikosteron MeSH
- sodík MeSH
The function of isolated perfused kidneys in post-DOCA phase of DOCA-salt hypertension was evaluated in rats subjected to DOCA-salt treatment either from youth or only in adulthood. Post-DOCA-salt hypertension was more severe in young than in adult animals. Kidneys isolated from young post-DOCA-salt hypertensive rats had higher renal vascular resistance when compared to adult ones. Perfusion of isolated kidneys over a wide range of perfusion pressure (110-170 mm Hg) has shown similar decrease of glomerular filtration, filtration fraction, diuresis and natriuresis in both age groups of DOCA-salt treated groups. Perfusion pressure-sodium excretion curves had reduced slope and were shifted to the right in both hypertensive groups, indicating huge glomerular damage. Nevertheless, the relative difference in glomerular filtration and sodium excretion between hypertensive rats and age-matched normotensive controls was always greater in younger animals. These results suggest that the more pronounced changes in glomerular hemodynamics and filtration could be involved in higher blood pressure-response of young animals to DOCA-salt treatment.
Citace poskytuje Crossref.org
Research on Experimental Hypertension in Prague (1966-2009)