A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods
Jazyk angličtina Země Irsko Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
10433374
DOI
10.1016/s0300-483x(98)00146-2
PII: S0300-483X(98)00146-2
Knihovny.cz E-zdroje
- MeSH
- cholinesterasové inhibitory otrava MeSH
- krysa rodu Rattus MeSH
- oximy terapeutické užití MeSH
- potkani Wistar MeSH
- pyridinové sloučeniny farmakologie terapeutické užití MeSH
- reaktivátory cholinesterázy terapeutické užití MeSH
- soman otrava MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- BI 6 MeSH Prohlížeč
- cholinesterasové inhibitory MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterázy MeSH
- soman MeSH
The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6(1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium+ ++/-2-butene dibromide), against the organophosphate soman was compared with oximes at present used (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) using in vitro and in vivo methods. H oximes HI-6 and HLö-7 seem to be the most efficacious acetylcholinesterase reactivators against soman according to the evaluation of their reactivating and therapeutic efficacy in vitro as well as in vivo. The new oxime BI-6 is not as effective as the H oximes against soman, nevertheless it is significantly more effective against soman than the currently available oximes, pralidoxime, obidoxime and methoxime, which failed to protect rats poisoned with supralethal doses of soman. Our results confirm that the reactivating efficacy of oximes evaluated by the methods in vitro closely correlates not only with the potency of oximes in vivo in reactivating soman-inhibited acetylcholinesterase but also with the ability to protect rats poisoned with supralethal doses of soman.
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