Vibrational circular dichroism (VCD) spectra of (+)-alpha-pinene solutions in carbon tetrachloride have been measured in the range of volume fractions 5-100% (v/v) in the mid-infrared region. The concentration dependence measured was statistically analyzed with the aim of obtaining a reliable correlation between the VCD band areas and the concentrations of individual enantiomers. The quality of the spectra was estimated by means of noise spectra which were defined as half the difference of the two following blocks of scans. In addition to this, the enantiomeric purity was studied. This study was carried out for both (+)- and (-)-alpha-pinene enantiomers in the range of the percent enantiomeric excess in the interval 10-100%. The relationship between VCD intensity and enantiomeric purity was determined by least-square regression and statistically evaluated. All measurements performed in this study were intended as a basic tool for testing of a new commercial VCD setup from Bruker. Copyright 2000 Wiley-Liss, Inc.

Department of Physics and Measurement Institute of Chemical Technology at Prague Czech Republic

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