Fyzikálnĕ chemické in vitro a in vivo studium depotizace cinchokainu v atelokolagenové plsti
[In vitro and in vivo physicochemical study of depot formation of cinchocaine in an atelocollagen matrix]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
10953469
- MeSH
- Anesthetics, Local chemistry MeSH
- Dibucaine chemistry MeSH
- Chemistry, Pharmaceutical MeSH
- Pharmaceutical Vehicles * MeSH
- Collagen * MeSH
- Delayed-Action Preparations chemistry MeSH
- Polarography MeSH
- Spectrophotometry MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anesthetics, Local MeSH
- atelocollagen MeSH Browser
- Dibucaine MeSH
- Pharmaceutical Vehicles * MeSH
- Collagen * MeSH
- Delayed-Action Preparations MeSH
The paper presents an introductory physicochemical study dealing with the preparation of atelocollagen felt saturated with local anesthetics, with the modelling of the release of the anesthetic from the collagen matrix in vitro, and with the checking of the corresponding analytical procedures (dc-polarography and UV-VIS spectrophotometry) for the determination of cinchocaine. The study is supplemented with experiments in vivo that confirm the usability of the new material for the depot formation of local anesthetics.
