Citlivý GC-MS průkaz benzodiazepinů v moci ve formĕ jejich trimethylsilylderivátů
[Sensitivity of GC-MS in the detection of benzodiazepines in the urine in the form of trimethylsilyl derivatives]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články
PubMed
11038668
- MeSH
- anxiolytika moč MeSH
- benzodiazepiny MeSH
- lidé MeSH
- plynová chromatografie s hmotnostně spektrometrickou detekcí * MeSH
- senzitivita a specificita MeSH
- trimethylsilylové sloučeniny moč MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- anxiolytika MeSH
- benzodiazepiny MeSH
- trimethylsilylové sloučeniny MeSH
A sensitive evidence of trace concentrations of benzodiazepines and their metabolites in urine can be enabled after special sample preparation including enzymatic hydrolysis, special solid phase extraction, silylation and following analysis by gas chromatography with mass spectrometry in electron impact mode. After optimalization of the procedure the extraction recovery values in the range 50-85% are achieved. The scale of retention times with basic mass spectral data are presented for the spectrum of silylated benzodiazepines which can overlap some gaps in the standard toxicological literature up to now available.
