Indikátory oxidacního stresu z hlediska kardiovaskulárních chorob. II. Dusíkaté látky, AGE-látky a antioxidanty
[Indicators of oxidative stress in cardiovascular diseases. II. Nitrogenous substances, AGE-substances and antioxidants]
Language Czech Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
11045175
- MeSH
- Antioxidants metabolism MeSH
- Cardiovascular Diseases metabolism MeSH
- Humans MeSH
- Oxidative Stress * MeSH
- Glycation End Products, Advanced metabolism MeSH
- Nitrogen Compounds metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antioxidants MeSH
- Glycation End Products, Advanced MeSH
- Nitrogen Compounds MeSH
By oxidation of nitrogen oxide nitrites and nitrates are formed which can be considered markers of inflammation. AGE-substances (products of advanced glycation) are formed not only from proteins (e.g. Hb-AGE) but also from lipids (AGE-LDL) and DNA (AGE-DNA) and lead to an increased number of mutations. They are toxic and are deposited in the vascular wall. They cause coagulopathy, stimulate cytokines and inactivate nitrogen oxide and thus prevent relaxation of the vascular wall. Extracellular superoxide dismutase (EC-SOD) has a variant (mutation Arg213Gly with a 4% incidence) which causes deterioration of the cardiac prognosis. Selenium deficiency leads also to an increased frequency of cardiovascular diseases.
