Chemoprotective potentials of homoisoflavonoids and chalcones of Dracaena cinnabari: modulations of drug-metabolizing enzymes and antioxidant activity
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11268108
DOI
10.1002/ptr.697
PII: 10.1002/ptr.697
Knihovny.cz E-resources
- MeSH
- Anticarcinogenic Agents pharmacology MeSH
- Antioxidants pharmacology MeSH
- Chalcone pharmacology MeSH
- Cytochrome P-450 CYP1A1 drug effects MeSH
- Flavonoids pharmacology MeSH
- Plants, Medicinal * MeSH
- Microsomes drug effects MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Lipid Peroxidation drug effects MeSH
- Plant Extracts pharmacology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anticarcinogenic Agents MeSH
- Antioxidants MeSH
- Chalcone MeSH
- Cytochrome P-450 CYP1A1 MeSH
- Flavonoids MeSH
- Plant Extracts MeSH
A series of homoisoflavonoids and chalcones, isolated from the endemic tropical plant Dracaena cinnabari Balf. (Agavaceae), were tested for their potential to inhibit cytochrome P4501A (CYP1A) enzymes and Fe-enhanced in vitro peroxidation of microsomal lipids in C57B1/6 mouse liver. The effects of the polyphenolic compounds were compared with those of prototypal flavonoid modulators of CYP1A and the well-known antioxidant, butylated hydroxytoluene. 2-Hydroxychalcone and partly 4,6-dihydroxychalcone were found to be strong inhibitors of CYP1A-dependent 7-ethoxyresorufin O-deethylase (EROD) activity in vitro comparable to the effects of quercetin and chrysin. The first screening of flavonoids and chalcones of Dracaena cinnabari for antioxidant activity was done in an in vitro microsomal peroxidation assay. While chalcones were shown to be poor antioxidants, 7,8-methylenedioxy-3(4-hydroxybenzyl) chromane, as one of the tested homoisoflavonoids, exhibited a strong antioxidant activity comparable to that of the strongest flavonol antioxidant, quercetin.
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