The association study of DRD2, ACE and AGT gene polymorphisms and metamphetamine dependence
Language English Country Czech Republic Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
11300226
Knihovny.cz E-resources
- MeSH
- Alleles MeSH
- Peptidyl-Dipeptidase A genetics MeSH
- Angiotensinogen genetics MeSH
- Adult MeSH
- Gene Frequency MeSH
- Genotype MeSH
- Humans MeSH
- Methamphetamine * MeSH
- Sex Characteristics MeSH
- Polymerase Chain Reaction MeSH
- Polymorphism, Restriction Fragment Length * MeSH
- Substance-Related Disorders genetics MeSH
- Receptors, Dopamine D2 genetics MeSH
- Deoxyribonucleases, Type II Site-Specific metabolism MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Peptidyl-Dipeptidase A MeSH
- Angiotensinogen MeSH
- Methamphetamine * MeSH
- Receptors, Dopamine D2 MeSH
- Deoxyribonucleases, Type II Site-Specific MeSH
- TCGA-specific type II deoxyribonucleases MeSH Browser
We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene, and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin. However, a significant difference in allele I frequency between male and female control groups for the I/D ACE polymorphism (p<0.03) was found.
