Antibiotic selective pressure and development of bacterial resistance
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11337221
DOI
10.1016/s0924-8579(01)00317-x
PII: S0924-8579(01)00317-X
Knihovny.cz E-resources
- MeSH
- Aminoglycosides MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Drug Resistance, Microbial MeSH
- Anti-Infective Agents pharmacology MeSH
- Fluoroquinolones MeSH
- Gram-Negative Bacteria drug effects isolation & purification MeSH
- Cross Infection drug therapy microbiology MeSH
- Lactams MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Aminoglycosides MeSH
- Anti-Bacterial Agents MeSH
- Anti-Infective Agents MeSH
- Fluoroquinolones MeSH
- Lactams MeSH
This study evaluates the development of resistance in Gram-negative rods to cefotaxime and ceftazidime, ofloxacin and ciprofloxacin, gentamicin and amikacin, meropenem and ampicillin/sulbactam over a five year period of use (1994-1998) at the University Hospital in Olomouc, Czech Republic. The development of bacterial resistance was linked with antibiotic use and hence selective pressure which was specific for the type of antibiotic and the bacterial species. Statistically significant correlations were found for the use of ofloxacin and resistance in Escherichia coli, Proteus vulgaris and Providencia rettgeri; cefotaxime and Enterobacter cloacae; ceftazidime and Acinetobacter spp., Enterobacter agglomerans and Proteus vulgaris; and gentamicin and Proteus mirabilis.
References provided by Crossref.org
Implementation of Antibiotic Stewardship in a University Hospital Setting
Antibiotic consumption and its influence on the resistance in Enterobacteriaceae
