The in vitro effect of imipenem and ofloxacin on enzymic activity of Klebsiella strains
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
11347265
DOI
10.1007/bf02817610
Knihovny.cz E-zdroje
- MeSH
- antiinfekční látky farmakologie MeSH
- imipenem farmakologie MeSH
- infekce bakteriemi rodu Klebsiella mikrobiologie MeSH
- Klebsiella klasifikace účinky léků enzymologie MeSH
- lidé MeSH
- lipasa metabolismus MeSH
- mikrobiální testy citlivosti MeSH
- ofloxacin farmakologie MeSH
- thienamyciny farmakologie MeSH
- ureasa metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiinfekční látky MeSH
- imipenem MeSH
- lipasa MeSH
- ofloxacin MeSH
- thienamyciny MeSH
- ureasa MeSH
Fifty seven Klebsiella strains, viz. K. pneumoniae (28), K. planticola (19), K. oxytoca (6), K. ornithinolytica (3) and K. terrigena (1) possessed lipolytic and urealytic activity. The effect of imipenem and ofloxacin at subinhibitory concentrations (sub-MICs) on these enzymic activities of 4 strains was studied. At all the concentrations tested (mainly at 1/4 of the MICs) imipenem enhanced lipase activity manifested by cleavage of the substrate Tween 20. The effect of ofloxacin was strain- and concentration-dependent but in most cases lipolytic activity was also increased. The antibiotics practically did not affect the urease activity of the strains.
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