The in vitro effect of imipenem and ofloxacin on enzymic activity of Klebsiella strains
Language English Country United States Media print
Document type Journal Article
PubMed
11347265
DOI
10.1007/bf02817610
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents pharmacology MeSH
- Imipenem pharmacology MeSH
- Klebsiella Infections microbiology MeSH
- Klebsiella classification drug effects enzymology MeSH
- Humans MeSH
- Lipase metabolism MeSH
- Microbial Sensitivity Tests MeSH
- Ofloxacin pharmacology MeSH
- Thienamycins pharmacology MeSH
- Urease metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Imipenem MeSH
- Lipase MeSH
- Ofloxacin MeSH
- Thienamycins MeSH
- Urease MeSH
Fifty seven Klebsiella strains, viz. K. pneumoniae (28), K. planticola (19), K. oxytoca (6), K. ornithinolytica (3) and K. terrigena (1) possessed lipolytic and urealytic activity. The effect of imipenem and ofloxacin at subinhibitory concentrations (sub-MICs) on these enzymic activities of 4 strains was studied. At all the concentrations tested (mainly at 1/4 of the MICs) imipenem enhanced lipase activity manifested by cleavage of the substrate Tween 20. The effect of ofloxacin was strain- and concentration-dependent but in most cases lipolytic activity was also increased. The antibiotics practically did not affect the urease activity of the strains.
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