IGFBP-1 a jeho protektivní úloha v patogenezi mikroangiopatie u diabetes mellitus 1. typu
[IGFBP-1 and its protective role in the pathogenesis of microangiopathy in type 1 diabetes mellitus]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
11392040
- MeSH
- Carotid Arteries physiopathology MeSH
- Diabetes Mellitus, Type 1 physiopathology MeSH
- Diabetic Angiopathies blood physiopathology MeSH
- Insulin-Like Growth Factor Binding Protein 3 blood MeSH
- Insulin-Like Growth Factor I analysis MeSH
- Skin blood supply MeSH
- Laser-Doppler Flowmetry MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipids blood MeSH
- Microcirculation MeSH
- Insulin-Like Growth Factor Binding Protein 1 blood physiology MeSH
- Blood Flow Velocity MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Insulin-Like Growth Factor Binding Protein 3 MeSH
- Insulin-Like Growth Factor I MeSH
- Lipids MeSH
- Insulin-Like Growth Factor Binding Protein 1 MeSH
BACKGROUND: The role of IGF-I/IGFBP's system in the pathogenesis of diabetic vascular complications is widely discussed in the literature. We studied the influence of this system on microvasculature in patients with type 1 diabetes with respect to the effect of IGFBP-1. METHODS AND RESULTS: 17 patients with type 1 diabetes were included in the study. We examined IGF-I, IGFBP-1 and IGFBP-3 serum levels, parameters of compensation of diabetes and basic values of lipid metabolism. The function of microvasculature was examined using the laser-Doppler system Periflux. We didn't found any relation between the total IGF-I serum levels, parameters of lipid metabolism or level of diabetes compensation and the degree of impairment of the function of microcirculation. IGFBP-1 serum levels positively correlated with the peak perfusion in thermal hyperaemia (r = 0.39; p < 0.03). IGFBP-3 serum levels did not affect the function of microcirculation. CONCLUSION: We can conclude that the activity of IGF-I/IGFBP's system belongs to factors contributing to the development of diabetic microangiopathy in type 1 diabetes. IGFBP-1 as the modulator of IGF-I activity plays probably protective role against the progression of microangiopathy. These results correspond with observations of some other authors.
