One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)

DUI

D018970 MeSH Browser

CUI

M0028341

Previous indexing

Carrier Proteins (1992-1995)

History note

2005(1992)

Public note

2005; see INSULIN-LIKE-GROWTH-FACTOR-BINDING PROTEIN-1 1996-2005; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 was indexed under CARRIER PROTEINS 1992-95