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NMR methodology for the study of nucleic acids

. 2001 Jun ; 11 (3) : 275-81.

Language English Country Great Britain, England Media print

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

During the past few years, NMR methodology for the study of nucleic acids has benefited from new developments that greatly improved state-of-the-art technology for the precise determination of three-dimensional structures. Substantial progress has been made in designing experimental protocols for the measurement of residual dipolar couplings, in sensitivity optimization of triple-resonance experiments and in detection of hydrogen bonds and in developing computational methods for structure refinement using NMR restraints.

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