Management of inoperable carcinoma of the breast by curative radiotherapy and chemo-hormonotherapy
Language English, German Country Switzerland Media print
Document type Journal Article
PubMed
11455219
DOI
10.1159/000055089
PII: 55089
Knihovny.cz E-resources
- MeSH
- Radiotherapy, Adjuvant MeSH
- Cisplatin administration & dosage adverse effects MeSH
- Cyclophosphamide administration & dosage adverse effects MeSH
- Adult MeSH
- Doxorubicin administration & dosage adverse effects MeSH
- Carcinoma, Ductal, Breast diagnostic imaging drug therapy mortality pathology MeSH
- Fluorouracil administration & dosage adverse effects MeSH
- Antineoplastic Agents, Hormonal administration & dosage adverse effects MeSH
- Combined Modality Therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Methotrexate administration & dosage adverse effects MeSH
- Survival Rate MeSH
- Breast Neoplasms diagnostic imaging drug therapy mortality pathology MeSH
- Follow-Up Studies MeSH
- Antineoplastic Combined Chemotherapy Protocols administration & dosage adverse effects MeSH
- Radiography MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cisplatin MeSH
- Cyclophosphamide MeSH
- Doxorubicin MeSH
- Fluorouracil MeSH
- Antineoplastic Agents, Hormonal MeSH
- Methotrexate MeSH
BACKGROUND: The aim of this study was to evaluate local control and its relation to survival in patients with locally advanced breast cancer treated with curative irradiation and systemic therapy. PATIENTS AND METHODS: 240 patients with unresectable breast cancer were treated with curative radio- and chemo- or hormonotherapy from 1990-1995. The frequency of distant dissemination and the overall survival of patients with and without complete local control were compared. RESULTS: Complete local control was achieved in 63% of patients. Complete local control correlated with decrease of distant metastases and increase of survival in comparison with patients without complete local control. CONCLUSION: Radiotherapy without surgery provides insufficient local control in patients with locally advanced breast cancer. Complete local control is an important factor for prevention of distant dissemination and for survival.
References provided by Crossref.org
