Relative pathogenicity of Candida tropicalis in rat tongue mucosa
Language English Country United States Media print
Document type Journal Article
PubMed
11501424
DOI
10.1007/bf02818727
Knihovny.cz E-resources
- MeSH
- Abscess etiology pathology MeSH
- Candida isolation & purification pathogenicity MeSH
- Tongue microbiology pathology MeSH
- Rats MeSH
- Humans MeSH
- Myositis etiology pathology MeSH
- Tongue Diseases etiology pathology MeSH
- Candidiasis, Oral etiology pathology MeSH
- Rats, Sprague-Dawley MeSH
- Mucous Membrane microbiology pathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
The potential of C. tropicalis to colonize and infect rat tongue mucosa was demonstrated. Thirty female Sprague-Dawley rats were infected orally with three different strains of C. tropicalis. The animals were killed one and three weeks following the inoculation and sections of their tongue were stained with hematoxylin-eosin and Grocott stain. Histological changes were observed in the group of animals killed one week after inoculation and infected with C. tropicalis strain isolated from the crural ulcer of a diabetic patient. The most important finding was acute purulent myositis with the formation of abscesses. The myositis was local without signs of spreading to the surrounding tissue. Epithelium-penetrating hyphae observed in the Grocott-stained sections were relatively fewer and more sparsely distributed.
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