Electrode potential-controlled DNA damage in the presence of copper ions and their complexes
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
11786333
DOI
10.1016/s1567-5394(01)00131-1
PII: S1567539401001311
Knihovny.cz E-zdroje
- MeSH
- elektrody * MeSH
- fenantroliny chemie MeSH
- kationty MeSH
- měď chemie MeSH
- poškození DNA * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 1,10-phenanthroline MeSH Prohlížeč
- fenantroliny MeSH
- kationty MeSH
- měď MeSH
Supercoiled (sc) DNA immobilized at the surface of a hanging mercury drop electrode was cleaved by reactive oxygen species generated by an electrochemically modulated reaction of copper ions, hydrogen peroxide and/or oxygen. The cleavage was observed in a certain potential region where redox cycling of DNA-bound Cu(II)/Cu(I) took place. In the presence of 1,10-phenanthroline the maximum efficiency of DNA cleavage was shifted to more negative potentials and the effect was enhanced.
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