Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twins
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, studie na dvojčatech
- MeSH
- dieta škodlivé účinky MeSH
- dospělí MeSH
- dvojčata monozygotní genetika MeSH
- estery cholesterolu krev chemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mastné kyseliny analýza krev chemie MeSH
- nemoci u dvojčat etiologie genetika MeSH
- obezita etiologie genetika metabolismus MeSH
- triglyceridy krev chemie MeSH
- tuková tkáň chemie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- studie na dvojčatech MeSH
- Názvy látek
- estery cholesterolu MeSH
- mastné kyseliny MeSH
- triglyceridy MeSH
Fourteen pairs of obese female monozygotic twins were recruited for a study of genetic influences on serum and adipose fatty acid (FA) composition. Following 1 wk of inpatient stabilization, fasting serum and adipose tissue obtained by surgical excision were analyzed by thin-layer and gas chromatography. Intrapair resemblances (IPR) for individual FA were assessed by Spearman rank correlation and by analysis of variance and were found in serum cholesteryl esters (CF), triglycerides (TG), and adipose TG. With two exceptions (CE linoleate and adipose eicosapentaenoate), these IPR were limited to the nonessential FA. Palmitate had significant IPR in four lipid fractions; in serum CE and adipose TG palmitate was strongly correlated with multiple measures of adiposity. In contrast to other lipid fractions, serum phosphatidylcholine (PC) FA had 12 [PR, of which 6 were essential FA including arachidonate (r = 0.76, P < 0.0005), eicosapentaenoate (r = 0.78, P < 0.0005), and docosahexaenoate (r = 0.86, P< 0.0001). The PC [PR could not be explained by analysis of preadmission 7-d food records. After dividing the pairs into two groups differing and nondiffering according to fat intake of individuals in the pair, there was no evidence of a gene-environment interaction between fat intake and FA composition. The IPR for nonessential FA indicate that there is active genetic control of either food choices or postabsorptive metabolic processing. The high level of IPR in the PC fraction in contrast to the other lipid fractions suggests strong genetic influence over selection of specific FA for this membrane fraction independent of diet.
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Clin Chim Acta. 1985 Jun 30;149(1):89-93 PubMed
Metabolism. 1993 Sep;42(9):1127-40 PubMed
Lipids. 1989 May;24(5):389-95 PubMed
Lipids. 1990 Dec;25(12):798-806 PubMed
Schizophr Res. 1991 Dec;6(1):1-7 PubMed
J Lipid Res. 1993 Sep;34(9):1515-26 PubMed
Am J Physiol. 1995 Nov;269(5 Pt 2):R1060-7 PubMed
N Engl J Med. 1990 May 24;322(21):1483-7 PubMed
Int J Obes Relat Metab Disord. 2000 Aug;24(8):1051-7 PubMed
Am J Clin Nutr. 2000 Jun;71(6):1470-7 PubMed
Metabolism. 1989 Feb;38(2):188-92 PubMed
Am J Clin Nutr. 1997 Jun;65(6):1774-82 PubMed
Biochim Biophys Acta. 1987 Sep 25;921(2):378-91 PubMed
Am J Clin Nutr. 1994 Jul;60(1):61-7 PubMed
Am J Clin Nutr. 1990 Mar;51(3):385-92 PubMed
Obes Res. 1993 Mar;1(2):118-25 PubMed
Ann N Y Acad Sci. 1963 Sep 26;110:113-40 PubMed
Br J Nutr. 1974 Jul;32(1):77-97 PubMed
Physiol Rev. 1994 Oct;74(4):761-811 PubMed
Diabetes. 1999 Jan;48(1):112-6 PubMed
Lipids. 1990 Sep;25(9):517-22 PubMed
Am J Clin Nutr. 1995 Mar;61(3 Suppl):721S-725S PubMed
J Clin Invest. 1991 May;87(5):1841-52 PubMed
Am J Clin Nutr. 1991 Jun;53(6):1372-7 PubMed
N Engl J Med. 1990 May 24;322(21):1477-82 PubMed
J Invest Dermatol. 1986 Jun;86(6):706-8 PubMed
Obes Res. 1993 May;1(3):206-22 PubMed
N Engl J Med. 1993 Jan 28;328(4):238-44 PubMed
Lipids. 1993 Nov;28(11):987-93 PubMed
J Biol Chem. 1957 May;226(1):497-509 PubMed
J Clin Invest. 1949 Jan;28(1):129-39 PubMed
Annu Rev Nutr. 1994;14:83-98 PubMed
Prog Lipid Res. 1981;20:897-9 PubMed
Sb Lek. 1995;96(3):257-67 PubMed
