Electrophoretic karyotyping of Candida albicans strains isolated from premature infants and hospital personnel in a neonatal intensive care unit
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
11899481
DOI
10.1007/bf02814438
Knihovny.cz E-resources
- MeSH
- Candida albicans genetics isolation & purification MeSH
- Fungemia microbiology MeSH
- Cross Infection microbiology transmission MeSH
- Intensive Care Units, Neonatal * MeSH
- Candidiasis epidemiology microbiology transmission MeSH
- Karyotyping MeSH
- Humans MeSH
- Infant, Premature blood MeSH
- Infant, Newborn MeSH
- Personnel, Hospital * MeSH
- Infectious Disease Transmission, Professional-to-Patient MeSH
- Prospective Studies MeSH
- Hand MeSH
- Nurses MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Geographicals
- Slovakia epidemiology MeSH
Electrophoretic karyotyping was used to compare DNA probes of yeasts isolated from blood of preterm neonates (n = 66) in a neonatal intensive care unit (NICU) and from the hands of healthy hospital personnel (n = 10). The yeasts were identified as Candida albicans using standard laboratory methods. DNA was extracted from yeasts and isolation of identical DNA strains from the pairs nurse-neonate suggested that one nurse transmitted one yeast strain by her hands to three neonates. Four neonates harbored two identical strains originating from two nurses, i.e. each nurse transmitted the same strain to two neonates. In the additional 7 cases transmission of 1 yeast strain by 1 nurse to 1 neonate was observed. Our data suggest that nonperinatal nosocomial transmission of C. albicans occurs in neonates, possibly via cross-contamination being transferred on hands of health care workers. The importance of careful hand washing of staff (health care workers) and other infection-control procedures (to prevent the nosocomial transmission of pathogens in the NICU environment) is emphasized.
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