Pokroky ve vývoji nových antimykobakteriálních látek. Alkylsulfanyl skupina--farmakofor antimykobakteriální aktivity
[Advances in the development of new antimycobacterial agents. The alkylsulfanyl group--a pharmacophore for antimycobacterial activity]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články, práce podpořená grantem
PubMed
11910738
- MeSH
- antituberkulotika chemie farmakologie MeSH
- heterocyklické sloučeniny chemie farmakologie MeSH
- Mycobacterium účinky léků MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antituberkulotika MeSH
- heterocyklické sloučeniny MeSH
Tuberculosis ranks among the most widely spread infectious diseases and the need to find new antituberculotics has become more and more urgent. The present review paper aims at the compounds containing an alkylsulfanyl group which can be considered the pharmacophore of antituberculotic activity. The alkylsulfanyl group is bound to various heterocycles, condensed systems, and there is also a bond to the aliphatic structure. The activities of some compounds discussed in the resent paper are comparable with those of the antituberculotics in current use and therefore they could be introduced into practice, or at least suggest further direction of development. The present survey is based on the journal Chemical Abstracts.
New S-benzylisothiosemicarbazones with antimycobacterial activity
New antimycobacterial S-alkylisothiosemicarbazones
