Hypoxia-induced lipid peroxidation in rat brain and protective effect of carnitine and phosphocreatine
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12396100
DOI
10.1023/a:1020339530924
Knihovny.cz E-zdroje
- MeSH
- fosfokreatin farmakologie MeSH
- hypoxie metabolismus MeSH
- karnitin farmakologie MeSH
- krysa rodu Rattus MeSH
- látky reagující s kyselinou thiobarbiturovou metabolismus MeSH
- mozek účinky léků metabolismus MeSH
- peroxidace lipidů * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- fosfokreatin MeSH
- karnitin MeSH
- látky reagující s kyselinou thiobarbiturovou MeSH
The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretreated with alpha-tocopherol, L-carnitine, or phosphocreatine had lower TBARS levels after the exposure to hypobaric hypoxia. However, lactate/ pyruvate ratio was improved only in rats pretreated with L-carnitine or phosphocreatine. We conclude from our data that, contrary to alpha-tocopherol, protective effects of L-carnitine and phosphocreatine administrations are due to their regulation of metabolic reactions during hypobaric hypoxia rather than to their scavenger activity.
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J Mol Neurosci. 2001 Apr-Jun;16(2-3):195-200; discussion 215-21 PubMed
Free Radic Biol Med. 1999 May;26(9-10):1158-65 PubMed
J Clin Invest. 1991 Dec;88(6):1886-93 PubMed
J Surg Res. 1995 Jul;59(1):198-204 PubMed
J Exp Med. 1987 Feb 1;165(2):500-14 PubMed
Circulation. 1993 Mar;87(3):972-81 PubMed
Mol Cell Biochem. 1998 Aug;185(1-2):65-75 PubMed
Ciba Found Symp. 1983;101:4-18 PubMed
Physiol Res. 1999;48(1):73-8 PubMed
J Neurochem. 1992 Nov;59(5):1609-23 PubMed
Int J Tissue React. 1999;21(1):1-6 PubMed
Int J Biochem Cell Biol. 2000 May;32(5):539-47 PubMed
J Neurochem. 1999 Oct;73(4):1674-82 PubMed
Physiol Res. 1992;41(3):207-12 PubMed
Arch Biochem Biophys. 1992 Aug 1;296(2):394-401 PubMed
J Cardiovasc Pharmacol. 1999 Nov;34(5):651-9 PubMed
Physiol Res. 1994;43(6):387-9 PubMed
Arch Biochem Biophys. 1991 Aug 1;288(2):533-7 PubMed
Am Heart J. 1979 Mar;97(3):375-88 PubMed
Brain Res. 1991 Jan 18;539(1):175-7 PubMed
Free Radic Biol Med. 1989;6(3):303-13 PubMed
Sangyo Eiseigaku Zasshi. 1995 Mar;37(2):75-82 PubMed
Anal Biochem. 1979 Jun;95(2):351-8 PubMed
Physiol Res. 2001;50(4):439-42 PubMed
Physiol Res. 1993;42(1):53-4 PubMed
Brain Res. 1992 Sep 11;590(1-2):334-6 PubMed
Nephron. 2000 Apr;84(4):362-6 PubMed
J Neurosci. 1997 Dec 1;17 (23 ):9060-7 PubMed
Neurosci Lett. 1996 Mar 15;206(2-3):121-4 PubMed
