Hypoxia-induced lipid peroxidation in rat brain and protective effect of carnitine and phosphocreatine
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Phosphocreatine pharmacology MeSH
- Hypoxia metabolism MeSH
- Carnitine pharmacology MeSH
- Rats MeSH
- Thiobarbituric Acid Reactive Substances metabolism MeSH
- Brain drug effects metabolism MeSH
- Lipid Peroxidation * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Phosphocreatine MeSH
- Carnitine MeSH
- Thiobarbituric Acid Reactive Substances MeSH
The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretreated with alpha-tocopherol, L-carnitine, or phosphocreatine had lower TBARS levels after the exposure to hypobaric hypoxia. However, lactate/ pyruvate ratio was improved only in rats pretreated with L-carnitine or phosphocreatine. We conclude from our data that, contrary to alpha-tocopherol, protective effects of L-carnitine and phosphocreatine administrations are due to their regulation of metabolic reactions during hypobaric hypoxia rather than to their scavenger activity.
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