Effect of outer-membrane permeabilizers on the activity of antibiotics and plant extracts against Pseudomonas aeruginosa
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12422514
DOI
10.1007/bf02818694
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- bakteriální léková rezistence MeSH
- citráty farmakologie MeSH
- citronan sodný MeSH
- EDTA farmakologie MeSH
- erythromycin farmakologie MeSH
- fosfáty farmakologie MeSH
- gentamiciny farmakologie MeSH
- muramidasa farmakologie MeSH
- permeabilita buněčné membrány účinky léků MeSH
- Pseudomonas aeruginosa účinky léků MeSH
- rifampin farmakologie MeSH
- rostlinné extrakty farmakologie MeSH
- vankomycin farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- citráty MeSH
- citronan sodný MeSH
- EDTA MeSH
- erythromycin MeSH
- fosfáty MeSH
- gentamiciny MeSH
- muramidasa MeSH
- rifampin MeSH
- rostlinné extrakty MeSH
- sodium polymetaphosphate MeSH Prohlížeč
- vankomycin MeSH
Several known outer membrane permeabilizers increased susceptibility of a highly resistant pathogenic strain Pseudomonas aeruginosa to different antibiotics and plant extracts. Of all the chemicals tested, EDTA, sodium citrate and sodium hexametaphosphate (HMP) were found to be potent permeabilizers as shown by enhanced lysis of the bacteria in the presence of lysozyme. In the presence of EDTA and sodium citrate susceptibility of the strain to gentamicin and rifampicin increased markedly. The strain was resistant to vancomycin but became susceptible when grown in the presence of increasing amounts of EDTA and sodium citrate. Similar results were obtained for erythromycin when treated with sodium citrate. EDTA was found to be most potent permeabilizer in enhancing the activity of the plant extracts. Though HMP was an effective permeabilizer it had a weak or no effect on the activity of the antibiotics and plant extracts.
Zobrazit více v PubMed
J Appl Microbiol. 1999 Jun;86(6):985-90 PubMed
Folia Microbiol (Praha). 2000;45(3):211-6 PubMed
Microbiol Rev. 1992 Sep;56(3):395-411 PubMed
Microbiol Rev. 1985 Mar;49(1):1-32 PubMed
Lett Appl Microbiol. 1999 Jan;28(1):13-6 PubMed
Lett Appl Microbiol. 2000 May;30(5):379-84 PubMed
Biochim Biophys Acta. 1958 Nov;30(2):225-32 PubMed
Planta Med. 1995 Aug;61(4):365-6 PubMed
Antimicrob Agents Chemother. 1974 Aug;6(2):200-6 PubMed
Lett Appl Microbiol. 2000 Apr;30(4):294-7 PubMed
Clin Microbiol Rev. 1999 Jan;12(1):147-79 PubMed
Planta Med. 1991 Feb;57(1):1-7 PubMed
Antimicrob Agents Chemother. 1984 Jul;26(1):48-52 PubMed
J Sci Ind Res (1942). 1946 Aug;5(2):31-5 PubMed
Lett Appl Microbiol. 1998 May;26(5):355-8 PubMed
Antimicrob Agents Chemother. 1989 Oct;33(10 ):1741-7 PubMed
J Bacteriol. 1985 Dec;164(3):1256-61 PubMed
Phytother Res. 2002 Mar;16 Suppl 1:S89-90 PubMed
