Hippocampus-dependent retrieval and hippocampus-independent extinction of place avoidance navigation, and stress-induced out-of-context activation of a memory revealed by reversible lesion experiments in rats
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
12479785
Knihovny.cz E-zdroje
- MeSH
- bludiště - učení fyziologie MeSH
- dominance mozková MeSH
- extinkce (psychologie) fyziologie MeSH
- fyziologický stres patofyziologie psychologie MeSH
- hipokampus účinky léků fyziologie MeSH
- krysa rodu Rattus MeSH
- plavání psychologie MeSH
- potkani Long-Evans MeSH
- rozpomínání fyziologie MeSH
- tetrodotoxin farmakologie MeSH
- učení vyhýbat se fyziologie MeSH
- vnímání prostoru fyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- tetrodotoxin MeSH
The use of reversible lesion techniques in memory research was pioneered in the laboratory of Jan Bures and Olga Buresova. We use the occasion of Jan's 75th birthday to briefly review the experimental utility of this approach. Two experiments from our current research are reported in which reversible lesioning methods are used to ask otherwise experimentally untenable questions about memory retrieval. The first experiment used intra-hippocampal injections of tetrodotoxin to temporarily inactivate the hippocampus during retrieval of a well-learned place avoidance navigation memory. This revealed that the hippocampus is necessary for place avoidance retrieval but that the extinction of place avoidance can occur independently of retrieving the memory and intact hippocampal function. The second experiment used KCl-induced cortical spreading depression in an interhippocampal transfer paradigm to demonstrate that a Y-maze memory that is learned by only one cortical hemisphere can be made to transfer to the other hemisphere by forcing the rat to swim, a unique stressful experience that occurred in a different apparatus, different behavioral context, and involved different behaviors than the Y-maze training. This demonstrates, we believe for the first time behaviorally, that memories can be activated outside of the behavioral context of their acquisition and expression in rats.
Behavioral evidence that segregation and representation are dissociable hippocampal functions