Genomic occurrence of microsatellites containing integral and non-integral repeat numbers
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12559947
DOI
10.1016/s0006-291x(02)02940-6
PII: S0006291X02029406
Knihovny.cz E-resources
- MeSH
- Databases, Nucleic Acid MeSH
- Genome * MeSH
- Nucleic Acid Conformation MeSH
- Yeasts genetics MeSH
- Humans MeSH
- Microsatellite Repeats * MeSH
- Mice MeSH
- Base Sequence MeSH
- Sequence Analysis, DNA MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
We calculated occurrences of all dinucleotide and trinucleotide microsatellites in the human, mouse, and yeast genomes. The microsatellites were considered separately not only according to the repeated dinucleotide or trinucleotide and the microsatellite length but also according to the starting/terminal nucleotide. The analysis showed that dramatically non-equal amounts occurred in the human genome of microsatellites that differed only by the terminal nucleotides. For example, the 23-mer (TTG)(7)TT occurs 635 times in the human genome whereas (GTT)(7)GT is present only three times in the human genome though the two 23-mers share a 22 nucleotide sequence. The dramatically non-equal occurrences of microsatellites differing only by the terminal nucleotides are observed for most dinucleotide and trinucleotide microsatellites and in all analyzed genomes. We suppose that the strikingly non-equal genomic occurrences of these closely related microsatellites originate from conformational properties of DNA.
References provided by Crossref.org
