The effect of apomorphine administration on smooth pursuit ocular movements in early Parkinsonian patients
Language English Country Great Britain, England Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
12573868
DOI
10.1016/s1353-8020(02)00015-9
PII: S1353802002000159
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Apomorphine pharmacology MeSH
- Adult MeSH
- Electrooculography methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Parkinson Disease physiopathology MeSH
- Pursuit, Smooth drug effects physiology MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Apomorphine MeSH
Electrooculography (EOG) recordings in 21 L-DOPA-naive patients suffering from Parkinson's disease (PD) were made before and after apomorphine subcutaneous administration (ASA). The effect of apomorphine on smooth pursuit eye movements (SPEM) was studied. Age-matched healthy subjects, who underwent SPEM recordings without the ASA procedure, were examined in order to compare baseline SPEM. EOG recordings were used to compare the patient group and the control group, and to compare the SPEM before and after ASA within the patient group. Significant differences in SPEM were found between both groups, as well as in the SPEM before and after ASA. The theory that SPEM is disturbed in early PD patients was confirmed. The dopaminergic control of horizontal SPEM is supposed.
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