An indirect immunofluorescence assay was performed to detect antibodies to Candida albicans blastospores and germ tubes. Serum specimens were obtained from 82 patients with neoplastic diseases in the orofacial region and thrush of the oral mucosa. C. albicans was identified in the oral cavity of 63 patients investigated but serum anti-Candida antibodies were detected in only 23 of them. Serological examination showed that titers of antibodies to C. albicans blastospores ranged from 1:20 to 1:1280. High titers from 1:640 to 1:1280 were detected in patients without antibiotic, cytostatic, or radiotherapeutic treatment. The titers of antibodies to C. albicans germ tubes ranged from 1:20 to 1:640. Our results indicate that titers of antibodies to the C. albicans germ tubes were lower and were detected in a smaller number of patients.

Department of Physiology Faculty of Medicine Safárik University 040 66 Kosice Slovakia

See more in PubMed

J Med Vet Mycol. 1992;30 Suppl 1:249-60 PubMed

Eur J Clin Microbiol Infect Dis. 1990 Mar;9(3):178-83 PubMed

Folia Microbiol (Praha). 2001;46(2):161-4 PubMed

Eur J Clin Microbiol. 1987 Apr;6(2):142-6 PubMed

Eur J Clin Microbiol Infect Dis. 1997 Jan;16(1):32-41 PubMed

Eur J Clin Microbiol Infect Dis. 1993 May;12(5):347-9 PubMed

Folia Microbiol (Praha). 2002;47(3):297-301 PubMed

Med Oncol. 1996 Dec;13(4):223-31 PubMed

Folia Microbiol (Praha). 2000;45(4):364-8 PubMed

The detection of anti-Candida antibodies on experimental animal models