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Fatty acid analysis of Stenotrophomonas maltophilia clinical strains showing different susceptibility to antibiotics at 30 and 37 degrees C

Folia microbiologica. 2002 ; 47 (6) : 742-6.

Folia Microbiol (Praha)
ISSN 0015-5632
Source

Language English Country United States Media print

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid12630330

PubMed 12630330
DOI 10.1007/bf02818682
Knihovny.cz E-resources

MeSH
Anti-Bacterial Agents pharmacology MeSH
Fatty Acids, Nonesterified metabolism MeSH
Humans MeSH
Microbial Sensitivity Tests MeSH
Stenotrophomonas maltophilia drug effects metabolism MeSH
Temperature MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH
Names of Substances
Anti-Bacterial Agents MeSH
Fatty Acids, Nonesterified MeSH

Isolates of Stenotrophomonas maltophilia species display the feature "temperature-dependent susceptibility" (TDS) to antibiotics. Both 30TDS strains (at least 4 times lower value of minimum inhibitory concentration (MIC) of an antibiotic at 30 than at 37 degrees C) and 37TDS strains (at least 4 times lower value of MIC at 37 than at 30 degrees C) were described. Changes in the distribution of saturated and unsaturated fatty acids (FA) at 30 and 37 degrees C were considered as one of possible causes of the TDS phenomenon. Gas chromatography was used to determine the distribution of individual FA in five 37TDS strains of S. maltophilia (Group I); in five strains with MIC values unaffected by the cultivation temperature (Group II) and in six 30TDS (four strains) or 30/37TDS (two strains) isolates (Group III). At identical temperatures, no statistically significant differences in the distribution of major FA (iso-15:0, anteiso-15:0, 16:0 and 16:1) were registered between individual groups. Statistically significant (p < 0.05) differences between groups were found in minor FA only (iso-16:0, iso-17:0 and iso-17:1). Distribution changes of cellular FA at 30 and 37 degrees C can be considered to play only a minor role in the formation of the TDS phenomenon.

Institutes of Microbiology and Pathological Physiology Faculty of Medicine Palacký University 775 15 Olomouc Czechia

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