Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Arachnid Vectors immunology microbiology MeSH
- Immunity, Cellular MeSH
- Cytokines genetics metabolism MeSH
- Francisella tularensis growth & development immunology MeSH
- Ixodes immunology microbiology MeSH
- Skin chemistry microbiology MeSH
- Lymph Nodes immunology microbiology MeSH
- RNA, Messenger analysis biosynthesis MeSH
- Guinea Pigs MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Specific Pathogen-Free Organisms MeSH
- Reverse Transcriptase Polymerase Chain Reaction MeSH
- Spleen immunology microbiology MeSH
- Salivary Glands chemistry physiology MeSH
- Tularemia immunology microbiology MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cytokines MeSH
- RNA, Messenger MeSH
Accelerated proliferation of the tick-borne bacterial pathogen Francisella tularensis was demonstrated in mice when the bacterium was injected together with salivary gland extract from Ixodes ricinus ticks. A significant increase in the numbers of bacteria was recorded in the dermal site of infection,the draining lymph nodes, and the spleen. Analysis of the expression of cytokine messenger ribonucleic acids showed polarization toward a Th2 profile. Salivary gland extract-mediated suppression of interleukin-12 and interferon-gamma, the cytokines required for the expression of the protective immunity against tularemic infection, apparently contributed to the decreased resistance against this tick-transmitted pathogen.
References provided by Crossref.org
Tick saliva in anti-tick immunity and pathogen transmission
