Ticks act as vectors of a wide range of infectious agents, far encompassing any other group of bloodsucking arthropods worldwide. The prevention of tick-borne diseases is strictly linked to the successful management of tick vector populations. The employ of repellents can represent a worth solution to avoid tick bites. It is widely adopted to protect travellers and pets exposed to ticks during limited periods of the year. The use of natural products as active ingredients in eco-friendly repellent formulations is currently a prominent research area, due to the wide diversity and high effectiveness of a number of plant-borne compounds, with special reference to essential oils (EOs) extracted from medicinal and aromatic species. Here, we reviewed current knowledge available on EOs tested as repellents against tick species of veterinary importance. Furthermore, we analysed the effectiveness of pure compounds isolated from EOs as tick repellents and their potential implications for practical use in the öreal world". A quantitative analysis of literature available is this research field was provided, along with its impact (i.e., in terms of citations over time) on the scientific community of researchers in tick control science and natural product chemistry. In the final sections, future outlooks are highlighted. We discussed major challenges to stabilize the most effective EOs and pure molecules, explore the synergistic and antagonistic effects in blends of EOs and/or pure constituents, standardize currently adopted testing methods, and evaluate non-target risks of herbal repellents.

Crop Research Institute Drnovska 507 161 06 Prague Czech Republic

Department of Agriculture Food and Environment University of Pisa Via del Borghetto 80 56124 Pisa Italy; The BioRobotics Institute Scuola Superiore Sant'Anna Viale Rinaldo Piaggio 34 56025 Pontedera Pisa Italy

References provided by Crossref.org

Essential Oils from Cameroonian Aromatic Plants as Effective Insecticides against Mosquitoes, Houseflies, and Moths

Potential of Essential Oils from Anise, Dill and Fennel Seeds for the Gypsy Moth Control

Fumigant effect of essential oils on mortality and fertility of thrips Frankliniella occidentalis Perg

Efficacy of Origanum syriacum Essential Oil against the Mosquito Vector Culex quinquefasciatus and the Gastrointestinal Parasite Anisakis simplex, with Insights on Acetylcholinesterase Inhibition

Exploring the Insecticidal Potential of Boldo (Peumus boldus) Essential Oil: Toxicity to Pests and Vectors and Non-target Impact on the Microcrustacean Daphnia magna