Cardiovascular risk factors in young Czech females with polycystic ovary syndrome
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12721172
DOI
10.1093/humrep/deg218
Knihovny.cz E-resources
- MeSH
- Anthropometry MeSH
- Adult MeSH
- Cholesterol, HDL blood MeSH
- Hypertension epidemiology MeSH
- Incidence MeSH
- Body Mass Index MeSH
- Cardiovascular Diseases etiology MeSH
- Blood Pressure MeSH
- Cholesterol, LDL blood MeSH
- Humans MeSH
- Glucose Intolerance etiology MeSH
- Risk Factors MeSH
- Case-Control Studies MeSH
- Polycystic Ovary Syndrome blood complications pathology physiopathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Cholesterol, HDL MeSH
- Cholesterol, LDL MeSH
BACKGROUND: Polycystic ovary syndrome (PCOS) could be associated with a variety of signs of metabolic syndrome. The aim of our study was to compare the cardiovascular risk factors in PCOS women and in a control group selected from a random population sample. METHODS AND RESULTS: 50 PCOS women with a mean (+/-SD) age of 30.7 +/- 4.2 years, and 335 controls with a mean age of 29.9 +/- 3.1 years selected from a random population sample of nine districts of the Czech Republic were compared for basic anthropometric characteristics, blood pressure, plasma lipids and fasting glucose. PCOS women had a significantly higher body mass index (BMI). After adjusting for BMI, PCOS women had higher blood pressure and LDL-cholesterol, and lower HDL and HDL-cholesterol/total ratio. Arterial hypertension was more prevalent in PCOS women than in controls. There was no difference in the prevalence of impaired fasting glucose between both groups. Impaired glucose tolerance was found in 11.8% of PCOS women. Diabetes mellitus was more frequent in PCOS families. CONCLUSIONS: Czech PCOS women, even in their thirties, show a significantly worse cardiovascular risk profile than a control group selected from a random population sample. The differences cannot be explained by obesity.
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