Glutathione metabolism of Acremonium chrysogenum in relation to cephalosporin C production: is gamma-glutamyltransferase in the center?
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
12800495
DOI
10.1007/bf02930947
Knihovny.cz E-zdroje
- MeSH
- Acremonium růst a vývoj metabolismus MeSH
- cefalosporiny biosyntéza MeSH
- gama-glutamyltransferasa metabolismus MeSH
- glutathion metabolismus MeSH
- methionin metabolismus MeSH
- oxidační stres MeSH
- regulace genové exprese u hub * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cefalosporiny MeSH
- cephalosporin C MeSH Prohlížeč
- gama-glutamyltransferasa MeSH
- glutathion MeSH
- methionin MeSH
Methionine increased the intracellular glutathione (reduced) (GSH) pool and the specific gamma-glutamyltransferase (gamma-GT) activity in the cephalosporin C (CPC) producer Acremonium chrysogenum. The accelerated turnover of GSH might be indicative of the existence of a functioning gamma-glutamate cycle, and might supply the CPC biosynthetic machinery with L-cysteine. The gamma-GT was not subject to nitrogen metabolic repression but was more active in cells exposed to different oxidative-stress-generating agents. Exogenous cysteine hindered both the uptake of methionine and the induction of gamma-GT, and was not beneficial for CPC production. There was no causal relationship between the redox status of the cells and the observed cell morphology.
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