Biological activities of Prunella vulgaris extract
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
14595592
DOI
10.1002/ptr.1324
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents administration & dosage pharmacology therapeutic use MeSH
- Antioxidants administration & dosage pharmacology therapeutic use MeSH
- Biphenyl Compounds MeSH
- Antineoplastic Agents, Phytogenic administration & dosage pharmacology therapeutic use MeSH
- Phytotherapy * MeSH
- Gram-Positive Bacteria drug effects MeSH
- Hemolysis drug effects MeSH
- Mitochondria, Liver drug effects MeSH
- Cations MeSH
- Rats MeSH
- Humans MeSH
- Copper MeSH
- Microbial Sensitivity Tests MeSH
- Mice MeSH
- Cell Line, Tumor drug effects MeSH
- Oxidation-Reduction drug effects MeSH
- Picrates MeSH
- Rats, Wistar MeSH
- Prunella * MeSH
- Plant Extracts administration & dosage pharmacology therapeutic use MeSH
- Free Radical Scavengers administration & dosage pharmacology therapeutic use MeSH
- Iron MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 1,1-diphenyl-2-picrylhydrazyl MeSH Browser
- Anti-Infective Agents MeSH
- Antioxidants MeSH
- Biphenyl Compounds MeSH
- Antineoplastic Agents, Phytogenic MeSH
- Cations MeSH
- Copper MeSH
- Picrates MeSH
- Plant Extracts MeSH
- Free Radical Scavengers MeSH
- Iron MeSH
The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition of in vitro human LDL Cu(II)-mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert-butyl hydroperoxide, or to Cu(II) and Fe(III) ions. OF also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of LTB(4) in bovine PMNL generated by the 5-lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells and mouse epidermal fibroblasts and a moderate OF antimicrobial activity on gram-positive bacteria. Rosmarinic, caffeic and 3-(3,4-dihydroxyphenyl)lactic acids exhibited less potent activity than the plant extract in all bioassays. The antioxidative, antimicrobial, together with antiviral effects offer good prospects for the medicinal applications of P. vulgaris.
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