Hyperoxia prevents carrageenan-induced enlargement of functional residual lung capacity in rats
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
14640898
Knihovny.cz E-resources
- MeSH
- Pneumonia, Aspiration chemically induced physiopathology MeSH
- Tidal Volume drug effects physiology MeSH
- Functional Residual Capacity drug effects physiology MeSH
- Hyperoxia physiopathology MeSH
- Carrageenan pharmacology MeSH
- Rats MeSH
- Oxygen pharmacology MeSH
- Respiratory Mechanics drug effects physiology MeSH
- Lung Volume Measurements MeSH
- Lung drug effects physiopathology MeSH
- Pulmonary Ventilation drug effects physiology MeSH
- Rats, Wistar MeSH
- Body Weight physiology MeSH
- Exhalation drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Carrageenan MeSH
- Oxygen MeSH
Experimental pneumonia induced by intratracheal application of carrageenan or paraquat increases the functional residual lung capacity (FRC) in rats. The mechanism of this increase is not clear, but a decrease in PO(2) may be involved. To test this possibility, we attempted to eliminate the PO(2) decrease in carrageenan-treated rats by exposing them to hyperoxia. Animals of the first group were exposed to 7 days of hyperoxia (F(I)O(2) 0.78-0.84, group Car+O(2)) after intratracheal application of carrageenan (0.5 ml of 0.7 % carrageenan in saline), whereas animals of the second group were given the same dose of carrageenan but breathed air (group Car+A). The third group of rats was kept for seven days in hyperoxia (group O(2)) and the fourth group served as controls (C). The animals were then anesthetized and intubated and their ventilatory parameters and FRC were measured during air breathing. Carrageenan application induced a FRC increase (Car+A 2.0+/-0.2 ml, C 1.6+/-0.1 ml), which was not seen in carrageenan-treated rats exposed to hyperoxia (Car+O(2) 1.6+/-0.1 ml). Hyperoxia alone did not affect the value of FRC (O(2) 1.5+/-0.1 ml). These results support the hypothesis that a decrease in PO(2) plays an important role in the carrageenan-induced increase of FRC in rats.