Possible metabolic pathways of conversion of formaldoxime and glyceryl trinitrate to NO
Language English Country Slovakia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
14661735
Knihovny.cz E-resources
- MeSH
- Metabolism physiology MeSH
- Methemoglobin chemistry MeSH
- Nitroglycerin chemistry MeSH
- Nitric Oxide chemical synthesis chemistry MeSH
- Oxidation-Reduction MeSH
- Oximes chemistry MeSH
- Oxyhemoglobins chemistry MeSH
- Superoxides chemistry MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- formaldoxime MeSH Browser
- Methemoglobin MeSH
- Nitroglycerin MeSH
- Nitric Oxide MeSH
- Oximes MeSH
- Oxyhemoglobins MeSH
- Superoxides MeSH
The oxidation of N-hydroxylated compounds may result in production of nitrogen oxides, including nitric oxide (NO). Oxidation may be independent on NO-synthase. Production of nitrites and nitrates via NO from formaldoxime and glyceryl trinitrate was studied and compared. Superoxide ion, ions Fe2+ and Fe3+, methemoglobin and methemoglobin + NADPH + methylene blue, oxyhemoglobin and oxyhemoglobin + NADPH + methylene blue in the presence of atmospheric oxygen were used as oxidoreductive agents. Formaldoxime (triformaxime) was chosen as a newly recognized atypical cyclic oxime which can be converted to NO and glyceryl trinitrate as a well-known NO donor of quite different structure. From the oxidoreductive agents used, glyceryl trinitrate was not converted to nitrites or nitrates by Fe2+ or Fe3+ and by methemoglobin alone. Formaldoxime was resistant to the action of superoxide ion and methemoglobin alone. Importance of these possible metabolic pathways for production of NO from examined vasodilators is discussed.
