Developmental changes of cytochrome c oxidase and citrate synthase in rat heart homogenate
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
14984324
Knihovny.cz E-resources
- MeSH
- Enzyme Activation MeSH
- Citrate (si)-Synthase metabolism MeSH
- Rats MeSH
- Mitochondria enzymology MeSH
- Myocardium enzymology MeSH
- Rats, Wistar MeSH
- Electron Transport Complex IV metabolism MeSH
- Heart growth & development MeSH
- Age Factors MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Citrate (si)-Synthase MeSH
- Electron Transport Complex IV MeSH
Activity of cytochrome c oxidase and citrate synthase in rat heart homogenates was determined in 5-, 15-, 28- and 60-day-old rats. The activity of both enzymes increased during postnatal development but their changes followed different kinetics. The membrane-bound cytochrome c oxidase reached its adult values during the early postnatal period, i.e. between days 5 and 15, whereas soluble matrix-localized citrate synthase also continued to increase between days 15 and 60. Our data indicate a relative excess of cytochrome c oxidase in neonatal cardiocytes.
Neonatal cardiac mitochondria and ischemia/reperfusion injury
