Minipig as a model for drug metabolism in man: comparison of in vitro and in vivo metabolism of propafenone
Jazyk angličtina Země Česko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
15037896
Knihovny.cz E-zdroje
- MeSH
- antiarytmika farmakokinetika MeSH
- jaterní mikrozomy metabolismus MeSH
- lidé MeSH
- miniaturní prasata MeSH
- modely u zvířat * MeSH
- prasata MeSH
- propafenon farmakokinetika MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- antiarytmika MeSH
- propafenon MeSH
To prove the suitability of minipigs as experimental animal in modeling of the drug metabolism and pharmacokine-tics in man, propafenone metabolism in vitro at the microsomal level as well as propafenone pharmacokinetics in the minipig was studied. The results were compared with those obtained for humans. It can be concluded that whereas the microsomal in vitro system of minipig may be a good model for drug metabolism in the man, the pharmacokinetics in the whole organism is more complex reflecting differences in substrate specificities of many enzymatic and transport systems. In this particular case, it has been documented that the glucuronidation of propafenone principal metabolite (5-hydroxypropafenone) is more efficient in the minipig.
Preclinical electrogastrography in experimental pigs
