Minipig as a model for drug metabolism in man: comparison of in vitro and in vivo metabolism of propafenone
Language English Country Czech Republic Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15037896
Knihovny.cz E-resources
- MeSH
- Anti-Arrhythmia Agents pharmacokinetics MeSH
- Microsomes, Liver metabolism MeSH
- Humans MeSH
- Swine, Miniature MeSH
- Models, Animal * MeSH
- Swine MeSH
- Propafenone pharmacokinetics MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Arrhythmia Agents MeSH
- Propafenone MeSH
To prove the suitability of minipigs as experimental animal in modeling of the drug metabolism and pharmacokine-tics in man, propafenone metabolism in vitro at the microsomal level as well as propafenone pharmacokinetics in the minipig was studied. The results were compared with those obtained for humans. It can be concluded that whereas the microsomal in vitro system of minipig may be a good model for drug metabolism in the man, the pharmacokinetics in the whole organism is more complex reflecting differences in substrate specificities of many enzymatic and transport systems. In this particular case, it has been documented that the glucuronidation of propafenone principal metabolite (5-hydroxypropafenone) is more efficient in the minipig.
Preclinical electrogastrography in experimental pigs
