The function of the blood aqueous barrier in eyes with emulsified silicone oil
Language English Country Sweden Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15073575
PII: NEL240603A12
Knihovny.cz E-resources
- MeSH
- Albumins metabolism MeSH
- Adult MeSH
- Emulsions pharmacology MeSH
- Blood-Aqueous Barrier drug effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Nephelometry and Turbidimetry MeSH
- Protons MeSH
- Aged MeSH
- Silicone Oils pharmacology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Albumins MeSH
- Emulsions MeSH
- Protons MeSH
- Silicone Oils MeSH
PURPOSE: To evaluate the function of the blood aqueous barrier(BAB) in the eyes with silicone oil emulsification (SOE). METHODS: Protein concentrations, expressed in albumin equivalents,were determined in aqueous humor of the eyes with SOE in 11 consecutive patients by means of proton nuclear magnetic resonance (1H NMR) spectroscopy. Correlations with various clinical factors were studied. RESULTS: Normal function of the BAB (albumin equivalents 1mg/ml and less was found in 8 eyes (73%) independently on underlying disease, early postoperative reaction after pars plana vitrectomy with SO implantation, degree of SOE and late postoperative complications. Increased permeability of the BAB (albumin equivalents equal 2, 3 and 6.5 mg/ml) was found in 3 eyes (27%) with recent acute complication (retinal detachment after SO removal in 2 eyes, and secondary angle closure glaucoma in 1 eye). CONCLUSION: SOE in vivo was associated with increased permeability of the BAB in the minority of the eyes. Other factors should be studied to explain the variability of SOE. 1H NMR spectroscopy might be a valuable method for the study of SOE.
