Validation of a capillary zone electrophoresis method for determination of rimantadine hydrochloride in Rimantadin100 tablets and the method application to dissolution test monitoring
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, validační studie
PubMed
15089046
DOI
10.1081/ddc-120028707
Knihovny.cz E-zdroje
- MeSH
- elektroforéza kapilární metody MeSH
- inhibitory syntézy nukleových kyselin analýza chemie MeSH
- rimantadin analýza chemie MeSH
- rozpustnost MeSH
- tablety MeSH
- Publikační typ
- časopisecké články MeSH
- validační studie MeSH
- Názvy látek
- inhibitory syntézy nukleových kyselin MeSH
- rimantadin MeSH
- tablety MeSH
A capillary zone electrophoretic method with indirect UV-detection for determination of rimantadine, an antiviral drug against influenza A, in tablets was validated. Instrumental precision, the method precision, accuracy, calibration curve linearity, selectivity, robustness, and time stability of the sample and the standard were tested. The method was also applied to monitor dissolution tests of the tablets. The possibility of addition of an internal standard for improvement of the method precision was discussed.
Citace poskytuje Crossref.org
