The important role of APOAV gene T-1131>C variant in determination of plasma triglyceride levels has been proved on many population studies. Recently, associations between C-1131 allele and higher mother's height as well as with longer fetal birth length were suggested. In 1,305 females, aged between 28 and 67 years and having at least one child, we have analyzed a putative association between T-1131>C APOAV variant (analyzed by PCR and restriction analysis) and body height. Mother's body height did not differ between T/T homozygotes (N = 1093, 162.5 +/- 6.5 cm) and C allele carriers (N = 212, 162.1 +/- 6.4 cm). Thus we have failed to confirm, that mothers with APOAV C-1131 allele are higher than T/T-1131 homozygotes.

Institute of Clinical and Experimental Medicine Prague Czech Republic

Lipids Health Dis. 2003 Nov 05;2:9. doi: 10.1186/1476-511X-2-9. PubMed

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Ward KJ, Shields B, Knight B, Salzmann MB, Hattersley AT, Frayling TM. Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy. Lipids Health Dis. 2003;2:9. doi: 10.1186/1476-511X-2-9. PubMed DOI PMC

Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science. 2001;294:169–73. doi: 10.1126/science.1064852. PubMed DOI

Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM, Cohen JC. Two independent apolipoprotein AV haplotypes influence human plasma triglyceride levels. Hum Mol Genet. 2002;11:3031–8. doi: 10.1093/hmg/11.24.3031. PubMed DOI

Nabika T, Nasreen S, Kobayashi S, Masuda J. The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese. Atherosclerosis. 2002;165:201–4. doi: 10.1016/S0021-9150(02)00252-6. PubMed DOI

Hubacek JA, Skodova Z, Adamkova V, Lanska V, Poledne R. The influence of APOAV polymorphisms (T-1131>C and S19>W) on plasma triglyceride levels and risk of myocardial infarction. Clin Genet. 2004;65:126–30. doi: 10.1111/j.0009-9163.2004.00199.x. PubMed DOI

Hubacek JA, Skodova Z, Adamkova V, Vrablik M, Horinek A, Lanska V, Ceska R, Poledne R. APOAV polymorphisms (T-1131/C and Ser19/Trp) influence plasma triglyceride levels and risk of myocardial infarction. Exp Clin Cardiol. 2004. PubMed PMC

Talmud PJ, Hawe E, Martin S, Olivier M, Miller GJ, Rubin EM, Pennacchio LA, Humphries SE. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet. 2002;11:3039–46. doi: 10.1093/hmg/11.24.3039. PubMed DOI

Seda O, Sedova L. New apoliprotein A-V: comparative genomics meets metabolism. Physiol Res. 2003;52:141–6. PubMed

Talmud PJ, Martin S, Taskinen MR, Frick MH, Nieminen MS, Kesaniemi YA, Pasternack A, Humphries SE, Syvanne M. APOA5 gene variants, lipoprotein particle distribution and progression of coronary heart disease: results from the LOCAT study. J Lipid Res. 2004;45:750–756. doi: 10.1194/jlr.M300458-JLR200. PubMed DOI

Coleman RA. Placental metabolism and transport of lipid. Fed Proc. 1986;45:2519–23. PubMed

Knopp RH, Bergelin RO, Wahl PW, Walden CE. Relationships of infant birth size to maternal lipoproteins, apoproteins, fuels, hormones, clinical chemistries, and body weight at 36 weeks gestation. Diabetes. 1985;Suppl 2:71–7. PubMed

Horinek A, Vrablik M, Ceska R, Adamkova V, Poledne R, Hubacek JA. T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals. Atherosclerosis. 2003;167:369–70. doi: 10.1016/S0021-9150(03)00022-4. PubMed DOI

Nolan CJ, Riley SF, Sheedy MT, Walstab JE, Beischer NA. Maternal serum triglyceride, glucose tolerance, and neonatal birth weight ratio in pregnancy. Diabetes Care. 1995;18:1550–6. PubMed

Hubacek JA, Adamková V, Ceska R, Poledne R, Horinek A, Vrablik M. New variants in the apolipoprotein AV gene in individuals with extreme triglyceride levels. Physiol Res. 2004;53:225–8. PubMed

Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology