MPEP, an antagonist of metabotropic glutamate receptors, exhibits anticonvulsant action in immature rats without a serious impairment of motor performance
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15279866
DOI
10.1016/j.eplepsyres.2004.04.008
PII: S0920121104000907
Knihovny.cz E-resources
- MeSH
- Excitatory Amino Acid Antagonists administration & dosage pharmacology MeSH
- Anticonvulsants administration & dosage pharmacology MeSH
- Epilepsy, Generalized chemically induced prevention & control MeSH
- Epilepsy, Tonic-Clonic chemically induced prevention & control MeSH
- Convulsants MeSH
- Rats MeSH
- Animals, Newborn growth & development physiology MeSH
- Pentylenetetrazole MeSH
- Motor Activity drug effects physiology MeSH
- Postural Balance drug effects MeSH
- Rats, Wistar MeSH
- Pyridines administration & dosage pharmacology MeSH
- Receptors, Metabotropic Glutamate antagonists & inhibitors MeSH
- Reflex drug effects MeSH
- Aging physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 6-methyl-2-(phenylethynyl)pyridine MeSH Browser
- Excitatory Amino Acid Antagonists MeSH
- Anticonvulsants MeSH
- Convulsants MeSH
- Pentylenetetrazole MeSH
- Pyridines MeSH
- Receptors, Metabotropic Glutamate MeSH
An antagonist of type I metabotropic glutamate receptors MPEP was found to exhibit anticonvulsant action in adult rodents. Present experiments were focused on action of this drug against pentetrazol-induced motor seizures in immature rats 12-, 18- and 25-days old. Dose of pentetrazol (100 mg/kg s.c.) was chosen to elicit minimal clonic seizures and (after a longer latency) generalized tonic-clonic seizures. Pretreatment with MPEP (doses from 10 to 80 mg/kg i.p.) resulted in a dose-dependent suppression of the tonic phase of generalized tonic-clonic seizures in all age groups studied. Efficacy of MPEP was higher and the effect lasted longer in 12- than in 25-day-old rats. In addition, minimal clonic seizures were suppressed in 18-day-old rats. Motor abilities of immature animals were not compromised by MPEP in doses of 20 and/or 40 mg/kg i.p., only righting reflex was a little slowed down in 12- and 18-day-old rats. In contrast to antagonists of ionotropic glutamate receptors anticonvulsant doses of MPEP do not induce unwanted side effects in motor performance of developing rats.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
